Title

Blood, Brains, and Biomarkers: A New Test to Diagnose Traumatic Brain Injury

Date

5-26-2016 11:30 AM

End Time

26-5-2016 12:15 PM

Location

Natural Sciences (NS) 101

Department

Chemistry

Session Chair

Arlene Courtney

Session Title

Chemistry Capstone Seminars

Faculty Sponsor(s)

Arlene Courtney

Presentation Type

Presentation

Abstract

Concussions, or mild traumatic brain injuries (mTBIs), are a common occurrence during any contact sport. The diagnosis of mTBI can be extremely difficult due to the range of symptoms and the lack of an objective diagnostic test. Recently, researchers have discovered several biomarkers that are associated with mTBI. Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase isozyme 1 (UCH-L1) are released into the blood stream following an mTBI event. These proteins can be isolated using an ELISA assay and quantified using spectrophotometry. GFAP concentration is directly related to the severity of the concussion, whereas UCH-L1 does not show such a clear relationship. This seminar will explore the usefulness and implications of these biomarkers to diagnose TBI events.

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May 26th, 11:30 AM May 26th, 12:15 PM

Blood, Brains, and Biomarkers: A New Test to Diagnose Traumatic Brain Injury

Natural Sciences (NS) 101

Concussions, or mild traumatic brain injuries (mTBIs), are a common occurrence during any contact sport. The diagnosis of mTBI can be extremely difficult due to the range of symptoms and the lack of an objective diagnostic test. Recently, researchers have discovered several biomarkers that are associated with mTBI. Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase isozyme 1 (UCH-L1) are released into the blood stream following an mTBI event. These proteins can be isolated using an ELISA assay and quantified using spectrophotometry. GFAP concentration is directly related to the severity of the concussion, whereas UCH-L1 does not show such a clear relationship. This seminar will explore the usefulness and implications of these biomarkers to diagnose TBI events.