Title

The Unique Metabolism of Lisdexamfetamine (AKA Vyvanse)

Date

5-26-2016 11:00 AM

End Time

26-5-2016 1:00 PM

Location

WUC Pacific Room

Department

Chemistry

Session Chair

Patricia Flatt

Session Title

Biochemistry and Forensic Science

Faculty Sponsor(s)

Patricia Flatt

Presentation Type

Poster session

Abstract

This poster reviews the metabolism of the prodrug form of d-amphetamine used for treatment of ADHD, lisdexamfetamine (AKA Vyvanse) and how it differs from the traditional amphetamine treatment of ADHD, Adderall. Lisdexamfetamine and Adderall both treat ADHD by providing amphetamine to the frontal lobe of the brain, mimicking nuerotransmitters that are deficient in ADHD patients. The way in which Vyvanse delivers amphetamine to the brain differs from Adderall as Adderall is already in the amphetamine form and Vyvanse has a protecting cap that must be metabolically cleaved off to release amphetamine (making Vyvanse a prodrug). This property allows Vyvanse to have different biological activities from Adderall. The activity and metabolism of Vyvanse compared with Adderall will be the focal point of this poster.

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May 26th, 11:00 AM May 26th, 1:00 PM

The Unique Metabolism of Lisdexamfetamine (AKA Vyvanse)

WUC Pacific Room

This poster reviews the metabolism of the prodrug form of d-amphetamine used for treatment of ADHD, lisdexamfetamine (AKA Vyvanse) and how it differs from the traditional amphetamine treatment of ADHD, Adderall. Lisdexamfetamine and Adderall both treat ADHD by providing amphetamine to the frontal lobe of the brain, mimicking nuerotransmitters that are deficient in ADHD patients. The way in which Vyvanse delivers amphetamine to the brain differs from Adderall as Adderall is already in the amphetamine form and Vyvanse has a protecting cap that must be metabolically cleaved off to release amphetamine (making Vyvanse a prodrug). This property allows Vyvanse to have different biological activities from Adderall. The activity and metabolism of Vyvanse compared with Adderall will be the focal point of this poster.